Guest stars, Alyson Stoner and Miranda Cosgrove help the Muppets Tonight gang members set up for some very special disco dance karaoke performances.
- Tales from the Vet: Dr. Phil Van Neuter tests out his latest creation, Petrification Potion 300.
- Musical #: I wanna Hold Your Hand (sung and performed by Rizzo and the rest of the Muppets Tonight gang members)
- Muppet Labs: Bunsen and Beaker demonstrate the Cartoonerific Camera 600.
- Grand Finale Musical #: Lean on Me (sung and performed by Alyson Stoner and Miranda Cosgrove with Kermit and the rest of the Muppets Tonight gang members)